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Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy

Advanced Functional Materials. 2024-09; 
Qianglan Lu , Ruiyue Chen , Fei Zeng, Zhiyong Liu, Yongchun Pan, Yanfeng Gao, Bangshun He and Yujun Song
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摘要

As a major component of tumor infiltration, tumor-associated macrophages (TAMs) primarily promote the M2 phenotype of tumors in the tumor microenvironment. Additionally, the overexpression of anti-phagocytic molecules in TAMs facilitates tumor cell evasion of TAMs’ phagocytic arrest. Therefore, there is an urgent need to develop a reliable strategy to reprogram TAMs for more effective anti-tumor outcomes. In this study, innovative inhalable bioorthogonal gene-editable microparticles (SPR) have been engineered that reprogram TAMs for lung cancer therapy based on spike-covered sunflower sporopollenin exine capsules (SECs). These microparticles utilize SECs as delivery vehicles, with reduced palladium (Pd) nanop... More

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