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CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy

EBioMedicine. 2024-02; 
Peixia Tang , Zhen Yu , Hao Sun 2, Lanting Liu , Lixin Gong , Teng Fang , Xiyue Sun , Shiyi Xie , Gang An 2, Zhenshu Xu 3, Lugui Qiu 4, Mu Hao
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Proteins, Expression, Isolation and Analysis The cell lysates were incubated with Protein A/G Magbeads (L00277, GenScript) for preclearing. Get A Quote

摘要

Background: Multiple myeloma (MM) is an incurable hematological malignancy of the plasma cells. The maintenance of protein homeostasis is critical for MM cell survival. Elevated levels of paraproteins in MM cells are cleared by proteasomes or lysosomes, which are independent but inter-connected with each other. Proteasome inhibitors (PIs) work as a backbone agent and successfully improved the outcome of patients; however, the increasing activity of autophagy suppresses the sensitivity to PIs treatment. Methods: The transcription levels of CRIP1 were explored in plasma cells obtained from healthy donors, patients with newly diagnosed multiple myeloma (NDMM), and relapsed/refractory multiple myeloma (RRMM) usi... More

关键词

Autophagy; CRIP1; Multiple myeloma; PIs resistance; Proteasome degradation.