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A Minimalist Pathogen-Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy

ADVANCED MATERIALS. 2024-08; 
Yu Miao , Le Niu , Xinying Lv , Qiang Zhang , Zhisheng Xiao , Zhaoxin Ji , Linfu Chen , Yi Liu , Nanhui Liu , Junjie Zhu , Yang Yang , Qian Chen
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Peptide Synthesis Sodium periodate (NaIO4) was obtained from Energy Chemical. Model antigenic peptide OVA257-280 (SIINFEKLTEWTSSNVMEERKIKV) and FITC-OVA257-280 were synthesized by GenScript. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) and Lipopolysaccharide (LPS) were purchased from Sigma-Aldrich. Get A Quote

摘要

Pathogen-mimicking nanoparticles have emerged at the forefront of vaccine delivery technology, offering potent immune activation and excellent biocompatibility. Among these innovative carriers, mannan, a critical component of yeast cell walls, shows promise as an exemplary vaccine carrier. Nevertheless, it faces challenges like unpredictable immunogenicity, rapid elimination, and limited antigen loading due to high water solubility. Herein, mannan with varying carbon chain ratios is innovatively modified, yielding a series of dodecyl chains modified mannan (Mann-C12). Through meticulous screening, a mannan variant with a 40% grafting ratio is pinpointed as the optimal vaccine carrier. Further RNA sequencing con... More

关键词

cancer vaccine; immunotherapy; mannan; minimalist nanovaccine; pathogen‐like carrier