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Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via Hypoxia-Inducible Factor-1α.

Am J Hematol.. 2013-11; 
Gonsalves CS, Crable S, Chandra S, Li W, Kalra VK, Joiner CH. Division of Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
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摘要

The potassium chloride co-transporters (KCC) family of proteins are widely expressed and are involved in the transepithelial movement of potassium and chloride ions and the regulation of cell volume. The KCC activity exhibit is high in reticulocytes, and contributes to dehydration of sickle red blood cells. Because plasma levels of both vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are elevated in sickle cell individuals, and VEGF has been shown to increase KCC expression in other cells, we hypothesized that VEGF and PlGF influence KCC expression in erythroid cells. Both VEGF and PlGF treatment of human erythroid K562 cells increased both mRNA and protein levels of KCC1, KCC3b and... More

关键词

KCC proteins; KCl Cotransport; Sickle cell disease; angiogenic growth factor; erythroid cells