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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Commun Biol. 2023-07; 
Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet
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Peptide Synthesis … polarity protein Scribble by the cell adhesion receptor TMIGD1 | Communications Biology … , -DPHSEAAA; peptides were obtained from Genscript. The following reagents were used: Dox … Get A Quote
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摘要

Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation. The tumor-suppressive activity of Scrib correlates with its membrane localization. Despite the identification of numerous Scrib-interacting proteins, the mechanisms regulating its membrane recruitment are not fully understood. Here, we identify the cell adhesion receptor TMIGD1 as a membrane anchor of Scrib. TMIGD1 directly interacts with Scrib through a PDZ domain-mediated interaction and recruits Scrib to the lateral membrane domain in epithelial cells. We characterize the association of ... More

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