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Custom Vector Construction | … Please let us know what you think of our products and services. … C-(k)DYK expression vector was purchased from Genscript (clone number: OHu04410) and transfected into 0.2 × 10 6 … | Get A Quote |
Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and is important for prostate cancer viability. EDEM3 is a mannosidase that trims mannose from mis-folded glycoproteins, tagging them for degradation through endoplasmic reticulum-associated degradation. Here, we find that is upregulated in prostate cancer, and this is linked to poorer disease-free survival. Depletion of EDEM3 from prostate cancer cells induces an ER stress transcriptomic signature, and EDEM3 overexpression is cyto-protective against ER stressors. expression also positively correlates with genes involved in the unfolded ... More