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Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Sci Transl Med. 2021-10;

Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary Peterson, Janie Liang, Nathan Beutler, Jonathan L Torres, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, Frances Eun-Hyung Lee, Rona S Weinberg, Iyadh Douagi, Robin Gross, Connie Schmaljohn, Amarendra Pegu, John R Mascola, Michael Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter D Crompton, Joshua Tan

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Recombinant Antibody Expression	… Antibody V H or V L sequences were cloned into plasmids containing an IgG1 or relevant light chain backbone (GenScript) and used to … For IgA1 or IgA2 antibodies, V H sequences were also cloned into plasmids containing the IgA1 or IgA2 constant region (GenScript). …	Get A Quote