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Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Front Immunol. 2020;

Marion Tarbe, Wei Dong, Guang Hu, Yongfen Xu, Jing Sun, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Xiuzhen Li, Qibin Leng

Products/Services Used	Details	Operation
Peptide Synthesis	… Peptide Synthesis. Peptides were synthesized by Genscript with a purity >95% confirmed by HPLC and mass spectrometry. All peptides were dissolved in DMSO at 10 mg/ml and stored at −20°C. Viruses, Cells, and Reagents …	Get A Quote

摘要

Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans. In addition, cross-reactive CD8 T cells induced by dengue virus (DENV) have been shown to play a protective role against Zika virus (ZIKV). However, how JEV exposure or vaccination affects ZIKV infection in humans remains unclear. In this report, epitope prediction algorithms were used to predict the cross-reactive CD8 T cell epitope restricted to human HLA between JEV and ZIKV. We found that these predicted CD8 T cell epitopes are immunogenic and cross-reactive in humanized HLA transgenic mice. Moreover, JEV vaccine immunization provided cross-protection against... More