unassigned: Circular RNAs (circRNAs) play important roles in hepatocellular carcinoma (HCC) development. The circRNA () is dysregulated in HCC, while the mechanism of in HCC development is largely unknown.
unassigned: Thirty paired cancer and adjacent normal tissues were harvested from HCC patients. SNU-387 and Huh7 cells were cultured in this study. , () and () abundances were measured via quantitative reverse transcription-polymerase chain reaction or Western blot. Cell viability, migration, invasion, colony ability, cell cycle distribution and apoptosis were assessed via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, transwell assay, colony formation assay and flow cytometry. The inte... More
unassigned: Circular RNAs (circRNAs) play important roles in hepatocellular carcinoma (HCC) development. The circRNA () is dysregulated in HCC, while the mechanism of in HCC development is largely unknown.
unassigned: Thirty paired cancer and adjacent normal tissues were harvested from HCC patients. SNU-387 and Huh7 cells were cultured in this study. , () and () abundances were measured via quantitative reverse transcription-polymerase chain reaction or Western blot. Cell viability, migration, invasion, colony ability, cell cycle distribution and apoptosis were assessed via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, transwell assay, colony formation assay and flow cytometry. The interaction among , and was tested via dual-luciferase reporter analysis. The anti-HCC role of knockdown in vivo was investigated using xenograft model.
unassigned: expression was enhanced in HCC tissue samples and cells. silence inhibited cell viability, migration, invasion and colony formation, induced cell cycle arrest at G0/G1 phase, and promoted apoptosis in HCC cells. was targeted via and knockdown reversed the suppressive effect of silence on HCC development. targeted to repress HCC development. could regulate expression by mediating . Down-regulation of decreased xenograft tumor growth.
unassigned: Knockdown of repressed HCC development by mediating / axis, indicating a new pathogenesis of HCC.
