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Synthesis and Application of Collagens for Assembling a Corneal Implant

Methods Mol Biol. 2020;

Elle Edin, Fiona Simpson, May Griffith

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Peptide Synthesis	… and C-terminal thioester to achieve selective head to tail polymerization of peptides under aqueous … Here, however, our exColA peptide is crosslinked without prior conjugation to a polymeric backbone … This service can be performed by commercial entities such as GenScript …	Get A Quote

摘要

Recombinant or artificial designer collagens have developed to a point where they are viable candidates for replacing extracted animal collagens in regenerative medicine applications. Biomimetic corneas made have shown promise as replacements for human donor corneas, and have previously been fabricated from several different collagens or collagen-like peptides (CLPs). Prokaryotic expression systems allow for cheap, rapid, gram scale production of collagens/CLPs. Here, we describe a procedure for production of collagen-like peptides for the manufacture of a biomimetic cornea.