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Socioeconomic Disadvantage, Chronic Stress, and Hippocampal Subfield Development in Children

Neurosci Insights. 2020-06-01; 
Emily C Merz, Xiaofu He, Brent Myers, Kimberly G Noble
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Gene Synthesis … Research in Wageningen, Netherlands (Schaart et al. 2004). The R sequence was synthesized by GenScript and modified to contain a SV40 nuclear localization signal (NLS) on the 3'end. The R gene was cloned into pTFUbiCre … Get A Quote

摘要

Recent findings indicate that hair cortisol concentrations significantly mediate associations between socioeconomic disadvantage and reduced hippocampal CA3 and dentate gyrus volumes in children. In this commentary, we discuss these results and highlight important future research directions, including focusing on hippocampal subfield structural development in relation to episodic memory and mental health; the mechanistic role of excitatory amino acids, such as glutamate; and how chronic stress and cognitive stimulation may make unique proximal contributions to socioeconomic differences in hippocampal subfield volume. Building on the findings in these ways will contribute to advances in strategies aimed at reduc... More

关键词

Dentate gyrus, childhood adversity, cortisol, hippocampus, memory