GenScript, Piscataway, NJ, USA) solutions were generated at 50 μM in TBS sample buffer with 2% DMSO (v/v), and diluted to 1.5625 μM. ...">
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Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis.

FASEB J.. 2011-12;  25(2):4184-97
De Rienzo G, Bishop JA, Mao Y, Pan L, Ma TP, Moens CB, Tsai LH, Sive H. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
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摘要

Disc1 is a schizophrenia risk gene that engages multiple signaling pathways during neurogenesis and brain development. Using the zebrafish as a tool, we analyze the function of zebrafish Disc1 (zDisc1) at the earliest stages of brain and body development. We define a ″ tool ″ as a biological system that gives insight into mechanisms underlying a human disorder, although the system does not phenocopy the disorder. A zDisc1 peptide binds to GSK3β, and zDisc1 directs early brain development and neurogenesis, by promoting β-catenin-mediated Wnt signaling and inhibiting GSK3β activity. zDisc1 loss-of-function embryos additionally display a convergence and extension phenotype, demonstrated by... More

关键词

Disc1; zebrafish; brain; neurons; GSK3β; pcp; mutant.