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Comparative effectiveness of different antiplatelet agents at reducing TNF‐driven inflammatory responses in a mouse model

Clinical and Experimental Pharmacology and Physiology. 2019-11; 
Hae‐Ri Lee Kyung‐Yeon Park Young‐Jin Jeong Tae‐Hwe Heo
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Catalog Antibody … p65, and non- phosphorylated p65 were purchased from Cell Signalling Technology (Beverly, MA, USA) GAPDH antibody was obtained from GenScript (Piscataway, NJ) Horseradish peroxidase (HRP)- conjugated goat anti … Get A Quote

摘要

Antiplatelet drugs are conventionally used as treatments because of their anti‐coagulation functions. However, their pleiotropic effects are of great significance to the treatment of ischaemic cardiovascular diseases. Many studies have reported that an excessive amount of inflammation driven by tumour necrosis factor (TNF) is closely related to the prevalence of atherosclerosis. As the drug selection criteria and evaluation methods related to the anti‐TNF activity of antiplatelet drugs remain limited, our investigation of these drugs should prove beneficial. In this study, we compared the anti‐TNF activity of three antiplatelet agents, namely clopidogrel, sarpogrelate, and cilostazol, using the TNF‐indu... More

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