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Gravimetric biosensor based on a capacitive micromachined ultrasonic transducer functionalized with peptide ligands

2017 IEEE SENSORS. 2017-11; 
M. M. Mahmud ; H. Reese ; A. Joshipura ; C. Seok ; F. Y. Yamaner ; M. Daniele ;
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Peptide Synthesis … Following functionalization with the thiol-PEG self- assembled monolayer, the acetylated peptide, Ac-HWRGWV (Genscript, Piscataway, NJ, USA), was grafted onto the surface using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) coupling chemistry [10] … Get A Quote

摘要

This work presents a gravimetric biosensor based on a capacitive micromachined ultrasonic transducer (CMUT). Resonant and acoustic wave devices have recently been studied extensively for chem/bio sensing applications. Small membrane mass and high resonance frequency along with high quality factor of CMUTs facilitate a highly sensitive biosensor system. The limit for the minimum detectable loaded mass per unit area achieved in this work is 0.44 ag/μm 2 . Here we demonstrate a selective human immune protein immunoglobulin G (IgG) sensor with hexamer peptide ligand HWRGWV.

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