| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | Twenty-four peptides were selected, from a range of previously identified peptides in Spanish dry-cured hams, according to potential bioactivity based on the length, molecular weight, sequence, and composition in amino acids (Table 1). The selected peptides were synthesised (GenScript Corporation, Piscataway, NJ, USA) and the purity checked through liquid chromatography-mass spectrometry (LC-MS) analysis. Peptide solutions (1 mM) were prepared for subsequent bioactivity assays. | Get A Quote |
Food-derived bioactive peptides are promising compounds for the prevention and treatment of cardiovascular diseases, the main cause of mortality in developed countries. The aim of this work was to determine the in vitro anti-inflammatory, antioxidant, and angiotensin I-converting enzyme (ACE-I) inhibitory activities of twenty-four peptides that were identified in Spanish dry-cured hams. For the first time, some peptides such as PSNPP, HCNKKYRSEM and FNMPLTIRITPGSKA showed anti-inflammatory activity expressed as platelet-activating factor-acetylhydrolase, autotaxin, and lipoxygenase inhibition. Peptides MDPKYR and TKYRVP were the strongest antioxidants, whereas GGVPGG, TKYRVP, and HCNKKYRSEM showed the highest A... More
