至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Magnetic Retrieval of Encapsulated Beta Cell Transplants from Diabetic Mice Using Dual-Function MRI Visible and Retrievable Microcapsules

Adv Mater. 2020; 
Delcassian D, , Luzhansky I, Spanoudaki V, Bochenek M, McGladrigan C, Nguyen A, Norcross S, Zhu Y, Shan CS, Hausser R, Shakesheff KM, Langer R, , , Anderson DG, , , .
Products/Services Used Details Operation
Gene Synthesis also receives licensing fees (to patents in which he was an inventor on) from, invested in, consults (or was on scientific advisory boards or boards of directors) for, lectured (and received a fee), or conducts sponsored research at MIT for which he was not paid for the following entities: 7th Sense, Abpro, Aleph Farms, Alkermes, Allevi, Alnylam, Arcadia Biosciences, Artificial Cells, Arsenal Medical, Avalon, BASF, Celero, Cellomics, Cellular Biomedical, Charles River Labs, Clarus, Clontech, Combined Therapeutics, Conference Forum, Crown Biosciences, Curis, Cygnal Therapeutics, Dewpoint, Domain, Eagle, Echo, Edigene, Editas, Evox, Fate Therapeutics, Frequency Therapeutics, Genscript, GlaxoSmithKline, Glycobia, Glympse, Greenlight, HKF Technologies, Horizon Discovery, Humacyte, Indivor, Inovio, Institute of Immunology, Integrated DNA Technologies, In Vivo Therapeutics, Jnana Therapeutics, Kensa, KSQ Therapeutics, Laderatech, Inc. Get A Quote

摘要

Encapsulated beta cell transplantation offers a potential cure for a subset of diabetic patients. Once transplanted, beta cell grafts can help to restore glycemic control; however, locating and retrieving cells in the event of graft failure may pose a surgical challenge. Here, a dual-function nanoparticle-loaded hydrogel microcapsule is developed that enables graft retrieval under an applied magnetic field. Additionally, this system facilitates graft localization via magnetic resonance imaging (MRI), and graft isolation from the immune system. Iron oxide nanoparticles encapsulated within alginate hydrogel capsules containing viable islets are transplanted and the in vitro and in vivo retrieval of capsules conta... More

关键词