| Products/Services Used | Details | Operation |
|---|---|---|
| Gene Synthesis | … Additionally, mouse Itgav cDNA (OriGene, Rockville, MD, USA) was cloned into the AgeI- NheI sites of the pUltra lentiviral vector, and mouse Itgb6 cDNA (GenScript, Piscataway, NJ, USA) was cloned into the AgeI-XbaI sites … | Get A Quote |
Uncontrolled activation of transforming growth factor (TGF)-β results in a wide range of pathologic conditions. Therapeutic interventions to regulate TGF-β signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates fibrosis in mice by inhibiting αv integrin-mediated activation of TGF-β. Del-1 bound to αvβ6 integrin, an important activator of TGF-β, and inhibited the binding of αvβ6 integrin to the latency-associated peptide (LAP), thereby suppressing αv integrin-mediated activation of TGF-β. Lack of Del-1 increased colocalization of αv integrin and LAP in the lungs, which was reversed by Del-1 supplem... More
