Products/Services Used | Details | Operation |
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Peptide Synthesis | 1. Companies manufacturing peptide SPOT arrays are JPT Peptide Technologies, GenScript, and ProImmune-thinkpeptides, but this list is far from complete and is not based on personal experience. | Get A Quote |
Reactive oxygen species (ROS) convey signals essential for proliferation, maintenance, and senescence of a growing list of cell types. Compartmentalization of these signals is integral to cell viability as well as the signaling pathways ROS direct. Redox-active endosomes (redoxosomes) are formed downstream of several ligand-activated receptors. NADPH oxidase (NOX) is a main component of redoxosomes, which recruits multiple proteins (Rac1, NOX2, p67phox, SOD1). Isolation of redoxosomes and evaluation of how superoxide (O2˙-) production directs receptor signaling at the level of the endosome have enabled a better understanding of biologic processes controlled by ROS. In this chapter, we will first review the maj... More