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1H, 15N, 13C resonance assignment of the human CD44 cytoplasmic tail (669-742).

Biomol NMR Assign. 2019;

Frühbauer B, Mateos B, Konrat R.

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Codon Optimization	… 2005) for human CD44 cytoplasmic codon-optimized cDNA was acquired from GenScript®, coding for a 78-residue construct comprising four non-canonical residues, followed by the two final residues of CD44's transmembrane domain and the 72 canonical residues of the …	Get A Quote

摘要

CD44 is a universally and abundantly expressed single-pass type I protein that spans the cytoplasmic membrane and is considered the principal receptor for hyaluronan in the extracellular matrix. CD44 exerts a multitude of biological functions, especially in cell adhesion and migration, and its deregulation has several pathological implications, including a putative role in cancer cell dissemination. Here we report the NMR chemical shift assignment of the recombinant intrinsically disordered CD44 cytoplasmic region (669-742).