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Novel Isatin-based activator of p53 transcriptional functions in tumor cells.

Mol Biol Res Commun. 2019;

Mirgayazova R, Khadiullina R, Mingaleeva R, Chasov V, Gomzikova M, Garanina E, Rizvanov A, Bulatov E,.

Products/Services Used	Details	Operation
Catalog Antibody	… T containing 5% (mass/vol) nonfat dried milk for 1 h at RT, incubated with primary anti-p53 antibodies (Abcam, USA) overnight at 4°C, and then with Anti-Mouse IgG–Peroxidase antibody (Sigma-Aldrich, USA) for 1 h THE Beta Actin Antibody [HRP] (GenScript, USA) was used …	Get A Quote

摘要

Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cel... More