资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.

Cell. 2018;

Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A.

Products/Services Used	Details	Operation
Peptide Synthesis	1230 Cell 173, 1217–1230, May 17, 2018 STAR+METHODS KEY RESOURCES TABLE REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies FITC, Mouse, Anti-Ki-67, Set BD PharMingen 556026 Anti-cleaved caspase-9 (Asp353) mouse-speciﬁc Cell Signaling Technology #9509 Anti-cleaved caspase-3 (Asp175) Cell Signaling Technology #9661 Anti-cleaved caspase-8 (Asp387) XP rabbit mAb Cell Signaling Technology #8592 Anti-rabbit caspase-1 p10 (M-20) Santa Cruz Biotechnology Sc-514 Rabbit anti-MLKL (phospho S345) mAb Abcam Ab196436 Rabbit anti-p62 antibody Cell Signaling Technology #5114 Mouse anti-LC3 mAb MBL M186-3 Mouse anti-HSP70 mAb In-house Clone N6 Mouse anti-CD4 In-house Clone YTA321 Mouse anti-CD4 In-house Clone H129 Mouse anti-CD8 In-house Clone YTS169 Chemicals, Peptides, and Recombinant Proteins BID BH3 peptide, amidated at C terminus Sequence: SESQEDIIRNIARHLAQVGDSMDRSIP PGLVNGL Genscript N/A Etoposide Pﬁzer 61007017 Tumor Necrosis Factor (TNF) In-house N/A Compound A Gift from TetraLogic Pharmaceuticals N/A iDUN Gift from TetraLogic Pharmaceuticals IDN-6556 Lipopolysaccharide (LPS) from E.	Get A Quote

摘要

Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. Our structural analysis of BOK suggests close resemblance to BAX and BAK structures. Notably, Bok-/-Bax-/-Bak-/- animals exhibited more severe defects and died earlier than Bax-/-Bak-/- mice, implying that BOK has overlapping roles with BAX and BAK during developmental cell death. By analyzing Bok-/-Bax-/-Bak-/- triple-knockout mice whose cells are incapable of undergoing intrinsic apoptosis, we identified tissues that formed well without this process. We provide evidence that necroptosis, pyroptosis, or autophagy does not su... More