IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development.

Chronic inflammation， including that driven by autoimmunity， is associated with the development of B-cell lymphomas. IL1R8 is a regulatory receptor belonging to the IL1R family， which negatively regulates NF-κB activation following stimulation of IL1R or Toll-like receptor family members. IL1R8 deficiency is associated with the development of severe autoimmune lupus-like disease in mice. We herein investigated whether concomitant exacerbated inflammation and autoimmunity caused by the deficiency of IL1R8 could recapitulate autoimmunity-associated lymphomagenesis. We thus monitored B-cell lymphoma development during the aging of IL1R8-deficient mice， observing an increased lymphoid cell expansion that evolved to diffuse large B-cell lymphoma (DLBCL). Molecular and gene-expression analyses showed that the NF-κB pathway was constitutively activated in / B splenocytes. In human DLBCL， had reduced expression compared with normal B cells， and higher expression was associated with a better outcome. Thus， silencing is associated with increased lymphoproliferation and transformation in the pathogenesis of B-cell lymphomas associated with autoimmunity.