| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | As we have previously demonstrated susceptibility for Hst-5 to proteolysis by C. albicans secreted proteases (25), we developed the KK variant via mutations of specific amino acid residues in Hst-5, as previously described (26). Therefore, in this study, we also aimed to comparatively evaluate the anti-candidal potency of the formulation with the KK peptide, to that with the native Hst-5 peptide. Both peptides were synthesized by GenScript (Piscataway, NJ) with ≥95% purity. | Get A Quote |
Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasis, there are currently no feasible therapeutic strategies for the prevention of this recurrent condition. We developed a peptide-based antimicrobial bioadhesive formulation specifically designed for oral topical formulation. In this study, we aimed to evaluate the applicability of the novel formulation for the prevention of C. albicans colonization on denture material and development of clinical di... More
