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Proteins, Expression, Isolation and Analysis | The possibility of LPS containment in TiO2 NPs 4 ACS Paragon Plus Environment Page 5 of 31 Journal of Agricultural and Food Chemistry 62 63 64 65 66 67 68 69 70 stock solutions was excluded by the Limulus amebocyte lysate (LAL) assay with ToxinSensor Chromogenic LAL Endotoxin Assay Kit (Genscript) previously (22). | Get A Quote |
Early stage exposure of foodborne substances, such as brightening agent titanium dioxide nanoparticles (TiO NPs), can cause long-term effects in adulthood. We aimed to explore the potential adverse effect of long-term dietary intake of TiO NPs. After feeding for 2-3 months from weaning, TiO NPs-exposed mice showed lower body weight and induced intestinal inflammation. However, this phenomenon was not observed in gut microbiota-removed mice. TiO NPs exposure rarely affected the diversity of microbial communities, but significantly decreased the abundance of several probiotic taxa including and . Additionally, TiO NPs aggravated DSS-induced chronic colitis and immune response in vivo, and reduced t... More