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Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping.

Commun Biol. 2019;

LaneRosemary，SimonThomas，VintuMarian，SolkinBenjamin，KochBarbara，StewartNicolas，Benstead-HumeGraeme，PearlFrances M G，CritchleyGiles，StebbingJustin，GiamasGeor

Products/Services Used	Details	Operation
Catalog Antibody	Primary antibodies: Anti-AnnexinA2 (Genscript A01471, 1/1000 dilution), anti-β-Actin (Abcam ab6276, 1/5000 dilu- tion), anti-CD-9 (System Biosciences EXOAB-CD9A-1, 1/10000 dilution), anti- CD44 (Cell Signaling #3570, 1/1000 dilution), anti-CD63 (System Biosciences EXOAB-CD63A-1, 1/10,000 dilution), anti-CD81 (System Biosciences EXOAB- CD81A-1, 1/10,000 dilution), anti-Fibronectin (Abcam ab2413, 1/1000 dilution), anti-HSP-70 (System Bisociences EXOAB-HSP70A-1,1/10,000 dilution), anti- NEFL (Cell Signaling #2837, 1/1000 dilution), anti-OLIG2 (Genscript A01474, 1/1000 dilution), and anti-PTEN (Cell Signaling #9188, 1/1000 dilution).	Get A Quote

摘要

Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids， recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up. The aim of the current study was to describe the protein content of sEVs produced by different GBM cell lines and patient-derived stem cells. Our results reveal that the content of the sEVs mirrors the phenotypic signature of the respective GBM cells， leading to the description of p... More