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Higher Levels of a Cytotoxic Protein， Vaginolysin， in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa.

Sex Transm Dis. 2018;

Nowak Rebecca G，Randis Tara M，Desai Purnahamsi，He Xin，Robinson Courtney K，Rath Jessica M，Glover Elbert D，Ratner Adam J，Ravel Jacques，Brotman Rebec

Products/Services Used	Details	Operation
Catalog Antibody	VLY concentration was determined by ELISA as previously described (11) with the exception that a mouse monoclonal anti-VLY antibody (GenScript; 1:250 dilution) was used as the primary antibody.	Get A Quote

摘要

Vaginolysin (VLY)， a cytotoxic protein produced by Gardnerella vaginalis， may contribute to bacterial vaginosis. We observed that women with G. vaginalis， low levels of lactobacilli， history of vaginal douching， higher Nugent scores， and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.