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Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ-induced oxidative stress.

J Nanobiotechnology. 2017; 
Amin Faiz Ul,Shah Shahid Ali,Badshah Haroon,Khan Mehtab,Kim Myeon
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Recombinant Proteins ) for 45 min (GenScript Corporation, USA). The cells were washed twice with PBS, and then coun Get A Quote

摘要

In order to increase the bioavailability of hydrophilic unstable drugs like anthocyanins, we employed a polymer-based nanoparticles approach due to its unique properties such as high stability, improved bioavailability and high water-soluble drug loading efficiency. Anthocyanins constitute a subfamily of flavonoids that possess anti-oxidative, anti-inflammatory and neuroprotective properties. However, anthocyanins are unstable because their phenolic hydroxyl groups are easily oxidized into quinones, causing a reduced biological activity. To overcome this drawback and improve the free radical scavenging capabilities of anthocyanins, in the current study we for the first time encapsulated the anthocya... More

关键词

Alzheimer’s disease,Anthocyanins,Neuroprotection,Oxidative stress,PLGA@PEG-nanoparti