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A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection.

PLoS Negl Trop Dis. 2019-04;

NoonJason B，SchwarzErich M，OstroffGary R，AroianRaf

Products/Services Used	Details	Operation
Codon Optimization	… The validated CDS sequences were sent to Genscript for P. pastoris codon-optimized DNA synthesis and the CDSs without native signal peptides (AceyCP1, nt 40–1,032; AceyCPL, nt 46–1,032; and AceySKPI3, nt 52–240) were subcloned into pPICZαA in-frame with yeast α …	Get A Quote

摘要

Human hookworms (Necator americanus， Ancylostoma duodenale， and Ancylostoma ceylanicum) are intestinal blood-feeding parasites that infect ~500 million people worldwide and are among the leading causes of iron-deficiency anemia in the developing world. Drugs are useful against hookworm infections， but hookworms rapidly reinfect people， and the parasites can develop drug resistance. Therefore， having a hookworm vaccine would be of tremendous benefit.