Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain， monounsaturated fatty acid synthesis.

Fatty acids (FAs) with a chain length of more than 18 carbon atoms (>?C18) are interesting for the production of specialty compounds derived from these FAs. These compounds include free FAs， like erucic acid (C22:1-Δ13)， primary fatty alcohols (FOHs)， like docosanol (C22:0-FOH)， as well as jojoba-like wax esters (WEs) (C38-WE to C44-WE)， which are esters of (very) long-chain FAs and (very) long-chain FOHs. In particular， FAs， FOHs and WEs are used in the production of chemicals， pharmaceuticals and cosmetic products. Jojoba seed oil is highly enriched in diunsaturated WEs with over 70?mol% being composed of C18:1-C24:1 monounsaturated FOH and monounsaturated FA moieties. In this study， we aim for the production of jojoba-like WEs in the yeast Saccharomyces cerevisiae by increasing the amount of very long-chain， monounsaturated FAs and simultaneously expressing enzymes required for WE synthesis.