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Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans.

ScientificWorldJournal. 2019-01;

Addai-MensahOtchere，GyamfiDaniel，AmponsahFrancis Agyei，Annani-AkollorMax Efui，DanquahKwabena Owusu，BoatengLillian，OwireduEddie-Williams，AfriyieEdward Y，DuneehRichard Vikpebah，AsareRenate，Ofosu NtiamoahDavid，BoatengRic

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Peptide Synthesis	… Materials: Peptides SEQ ID NO:1: (KVKGKCKV) 3 KVKGKCKY (“P1”) and SEQ ID NO:2: (EVEGECEV) 3 EVEGECEY (“N1”) (Genscript, Inc., USA) are oppositely charged at neutral pH due to protonation of lysine (K) and deprotonation of glutamic acid (E). The other amino acid …	Get A Quote

摘要

The pathophysiology of malaria-related anaemia is not fully understood although increased destruction of parasitized and nonparasitized erythrocytes， as well as inadequate erythropoiesis， has been proposed. Circulating antierythropoietin (anti-EPO) antibodies have also been implicated in malaria and malaria-related anaemia in mice. However， studies on this association have not been investigated in humans. This study therefore determined the prevalence of anti-EPO antibody production and assessed its association with malaria and malaria-related anaemia in humans.