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Surface Modification of Polymeric Nanoparticles with M2pep Peptide for Drug Delivery to Tumor-Associated Macrophages.

Pharm. Res.. 2019-03;

PangLiang，PeiYihua，UzunalliGozde，HyunHyesun，LyleL Tiffany，Yeo

Products/Services Used	Details	Operation
Peptide Synthesis	… Human serum albumin was purchased from Sigma-Aldrich (St. Louis, MO). M2 peptide (M2pep, YEQDPWGVKWWY; N to C terminus) and WR12 (RWWRWWRRWWRR; N to C terminus) were custom-synthesized by GenScript USA (Piscataway, NJ) …	Get A Quote

摘要

Tumor-associated macrophages (TAMs) with immune-suppressive M2-like phenotype constitute a significant part of tumor and support its growth， thus making an attractive therapeutic target for cancer therapy. To improve the delivery of drugs that control the survival and/or functions of TAMs， we developed nanoparticulate drug carriers with high affinity for TAMs.