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Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model.

Xenotransplantation. 2013;

BradyJamie L，SutherlandRobyn M，HancockManuela，KitsoulisSusie，LahoudMireille H，PhillipsPeta M，HawthorneWayne J，d'ApiceAnthony J F，CowanPeter J，HarrisonLeonard C，O'ConnellPhilip J，LewAndr

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Codon Optimization	… The codon optimized DNA was synthesized by GenScript (GenScript USA Inc., Piscataway,NJ, USA) as a single multi‐gene cassette utilizing the furin/F2A 'ribosomal skip' signal to combine the heavy and light chain sequences 21. CD5L‐hIgG3 …	Get A Quote

摘要

We investigated whether graft produced anti-human CD2， mediated by adenovirus (Adv) transduction of pig neonatal islet cell clusters (pNICC)， would protect xenografts in a humanized mouse model from immune attack and whether such immunosuppression would remain local.