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Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV-16/18 antibodies.

Cancer Med. 2019-07; 
RosillonDominique,BarilLaurence,Del Rosario-RaymundoMaria Rowena,WheelerCosette Marie,SkinnerSusan Rachel,GarlandSuzanne Marie,SalmeronJorge,Lazcano-PonceEduardo,VallejosCarlos Santiago,StoneyTanya,Ter HarmselBram,LimTimothy Yong Kuei,QuekSwee Chong,MinkinaGalina,McNeilShelly Ann,BouchardCeline,FongKah Leng,MoneyDeborah,IlancheranArunachalam,SavichevaAlevtina,CruickshankMargaret,ChatterjeeArchana,FianderAlison,MartensMark,BozonnatMarie Cecile,StruyfFrank,DubinGary,CastellsaguéXa
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Peptide Synthesis … Isolated splenocytes in R10 medium were counted and added in triplicate wells at 2×105 cells per well. Two sets of peptides spanning the consensus E6/E7 sequence for HPV6 and HPV11 were reconstituted in DMSO (GenScript USA, Piscataway, NJ) … Get A Quote

摘要

Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree of protection from naturally acquired anti-HPV antibodies is uncertain. We examined the risk of HPV infections as defined by HPV DNA detection and cervical abnormalities among women >25 years in the Human Papilloma VIrus Vaccine Immunogenicity ANd Efficacy trial's (VIVIANE, NCT00294047) control arm.

关键词

cervical abnormality,human papillomavirus infection,naturally acquired antibodies,redetection or reactivation of HPV infection,risk reduc