Butadiene is a platform chemical used as an industrial feedstock for the manufacture of automobile tires， synthetic resins， latex and engineering plastics. Currently， butadiene is predominantly synthesized as a byproduct of ethylene production from non-renewable petroleum resources. Although the idea of biological synthesis of butadiene from sugars has been discussed in the literature， success for that goal has so far not been reported. As a model system for methanol assimilation， Methylobacterium extorquens AM1 can produce several unique metabolic intermediates for the production of value-added chemicals， including crotonyl-CoA as a potential precursor for butadiene synthesis.
Butadiene is a platform chemical used as an industrial feedstock for the manufacture of automobile tires， synthetic resins， latex and engineering plastics. Currently， butadiene is predominantly synthesized as a byproduct of ethylene production from non-renewable petroleum resources. Although the idea of biological synthesis of butadiene from sugars has been discussed in the literature， success for that goal has so far not been reported. As a model system for methanol assimilation， Methylobacterium extorquens AM1 can produce several unique metabolic intermediates for the production of value-added chemicals， including crotonyl-CoA as a potential precursor for butadiene synthesis.
