资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization.

Cell Commun. Signal. 2019-06;

FengJuan，DongChang，LongYanlan，MaiLifang，RenMeng，LiLingyi，ZhouTi，YangZhonghan，MaJianxing，YanLi，YangXia，GaoGuoquan，QiWe

Products/Services Used	Details	Operation
Catalog Antibody	IgG (Sigma-Aldrich, St. Louis, MO, USA) or KBP-neutralizing antibody (Genscript, China) was intraperitoneally administered to the diabetic mice every day beginning three days before the establishment of a wound model for 15 days.	Get A Quote

摘要

The accumulation of M1-polarized macrophages and excessive inflammation are important in the pathogenesis of diabetic foot ulcer (DFU). However， the underlying mechanism of DFU pathogenesis and the crucial regulators of DFU are less well known. Our previous study reported that kallikrein-binding protein (KBP)， an angiogenesis inhibitor， was significantly upregulated in diabetic patients compared to its levels in controls. The effects of KBP on monocyte chemotaxis and macrophage M1 polarization were elucidated in this study.