Products/Services Used | Details | Operation |
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Proteins, Expression, Isolation and Analysis | The proteins (40 μg/well) were subjected to ExpressPlusTM PAGE Gel for electrophoresis 6 (Genscript, Nanjing, China) and then transferred onto PVDF membranes. | Get A Quote |
Complement 5a (C5a) is able to induce the proliferation of human nasopharyngeal carcinoma (NPC) cells. Therefore, an effective method or drug that can specifically inhibit C5a-induced proliferation of human NPC cells needs to be developed. Reportedly, Apigenin has antiproliferative effects on a variety of cancer cells. However, the effect of Apigenin on NPC cell proliferation and its underlying mechanism are still unclear. Herein, the present study aimed to evaluate the effect of Apigenin on C5a-induced proliferation of human NPC cells and its possible mechanism through down-regulation of C5aR. We revealed that Apigenin could not only inhibit proliferation of NPC cells and but also reduce the expressio... More