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An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels.

J. Gen. Virol.. 2018;

DelatorreEdson，MirandaMilene，TschoekeDiogo A，Carvalho de SequeiraPatrícia，Alves SampaioSimone，Barbosa-LimaGiselle，Rangel VieiraYasmine，LeomilLuciana，BozzaFernando A，Cerbino-NetoJosé，BozzaPatricia T，Ribeiro NogueiraRita Maria，BrasilPatrícia，ThompsonFabiano L，de FilippisAna M B，SouzaThiago More

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Catalog Antibody	Quantitative real time RT-PCR was performed [13] with a Rotor-Gene thermocycler (Qiagen, Düsseldorf, Germany) with a QuantiTect probe enzyme kit (Qiagen). Customized synthetic RNA (GenScript, Inc., Piscataway, NJ, USA) was used for the standard curve.	Get A Quote

摘要

Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG， together with enhanced TNF-alpha levels， may have contributed to ZIKV invasion in the CSF， whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF， serum， saliva and urine).