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Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal.

Cancer Manag Res. 2018;

YinXiteng，WeiZheng，SongChuanhui，TangChuanchao，XuWenguang，WangYufeng，XieJunqi，LinZitong，Ha

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摘要

The objectives of this study were to explore the mechanisms of metformin sensitization to hypoxia-induced gefitinib treatment in resistant head and neck squamous cell carcinoma (HNSCC) and evaluate the effects of this combined treatment strategy.