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An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application.

Chem Biol Drug Des. 2017;

ChouFeng-Pai，TsaiChia-Tse，ChiouYa-Sheng，ChenYi-Ju，LiMeng-Erh，GuoTing-Wei，LyuJason WenJay，ChouSheng-Hao，WuTung-

Products/Services Used	Details	Operation
Codon Optimization	… The artificial gene‐encoded hp0421 from H. pylori was synthesized by the GenScript Corporation, and the codon sequence was optimized for expression in …	Get A Quote

摘要

Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness， illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.