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Helix-A peptide prevents gp120-mediated neuronal loss.

Mol Brain. 2019;

AvdoshinaValeria，TaraballiFrancesca，TasciottiEnnio，ÜrenAykut，MocchettiI

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Peptide Synthesis	… its binding to MTs. Fig. 1 Fig. 1. Fig. 1 The neuroprotective effect of peptides against gp120 depends on their binding to MTs. a. Helix-A and other peptides were purchased from Genscript, Piscataway, NJ. The binding affinity of …	Get A Quote

摘要

The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders. The neurotoxic effect of gp120 appears to occur through the α-helix motif that binds to neuronal microtubules (MTs). In this study， we examined the ability of short peptide derivatives from Helix-A， a peptide synthesized based on α-helix structure of gp120， to displace gp120 from binding to MTs and prevent its neurotoxic effects.