The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls.

Acanthamoeba castellanii， which causes keratitis and blindness in under-resourced countries， is an emerging pathogen worldwide， because of its association with contact lens use. The wall makes cysts resistant to sterilizing reagents in lens solutions and to antibiotics applied to the eye.