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Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies.

European Journal of Medicinal Chemistry. 2016;

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Proteins, Expression, Isolation and Analysis	Following washing with TBS-T, proteins were detected by chemiluminescence using the enhanced chemiluminescence system (GenScript Piscataway, NJ, USA) on a Fluorochem 8800 imaging station (AlphaInnotech, CA, USA).	Get A Quote

摘要

In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPS and DKK1， regulate Wnt signaling pathway and affect Tau phosphorylation. The current efforts resulted in the identification of potent DKK1 inhibitors which are able to inhibit prostaglandin J2-induced tau phosphorylation at serine 396.