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Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.

Antioxid. Redox Signal.. 2016;

Gorelenkova MillerOlga，BehringJessica Belle，SiedlakSandra L，JiangSirui，MatsuiReiko，BachschmidMarkus M，ZhuXiongwei，MieyalJo

Products/Services Used	Details	Operation
Catalog Antibody	NADPH and TNF-α were purchased from Roche. Cysteinyl glutathione disulfide (CSSG) was purchased from Toronto Research Chemicals. Anti-Grx1 antibody was custom generated by Genscript.	Get A Quote

摘要

Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis， and diabetes is implicated as a potentially predisposing condition. Remarkably， upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts， including diabetes. In this study， we investigated the potential impact of Grx1 upregulation in the central nervous system on dopaminergic (DA) viability.