Drosophila dorso-ventral (DV) patterning is one of the best-understood regulatory networks to date， and illustrates the fundamental role of enhancers in controlling patterning， cell fate specification， and morphogenesis during development. Histone acetylation such as H3K27ac is an excellent marker for active enhancers， but it is challenging to obtain precise locations for enhancers as the highest levels of this modification flank the enhancer regions. How to best identify tissue-specific enhancers in a developmental system de novo with a minimal set of data is still unclear.
Drosophila dorso-ventral (DV) patterning is one of the best-understood regulatory networks to date， and illustrates the fundamental role of enhancers in controlling patterning， cell fate specification， and morphogenesis during development. Histone acetylation such as H3K27ac is an excellent marker for active enhancers， but it is challenging to obtain precise locations for enhancers as the highest levels of this modification flank the enhancer regions. How to best identify tissue-specific enhancers in a developmental system de novo with a minimal set of data is still unclear.
