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Discovery of novel phenoxazinone derivatives as DKK1/LRP6 interaction inhibitors: Synthesis， biological evaluation and structure-activity relationships.

Bioorg. Med. Chem.. 2016-03;

ThysiadisSavvas，MpousisSpyros，AvramidisNicolaos，KatsamakasSotirios，BalomenosAthanasios，RemelliRosaria，EfthimiopoulosSpyros，SarliVasi

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Proteins, Expression, Isolation and Analysis	Following washing with TBS-T, proteins were detected by chemiluminescence using the enhanced chemiluminescence system (GenScript Piscataway, NJ, USA) on a Fluorochem 8800 imaging station (Alpha Innotech, CA, USA).	Get A Quote

摘要

Amino derivatives of NCI8642 were synthesized and evaluated as inhibitors of DKK1/LRP6 interactions. The new inhibitors were able to activate the Wnt signaling pathway as indicated by the increased levels of β-catenin， and decrease the DKK1-induced Tau phosphorylation at serine 396.