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Proteins, Expression, Isolation and Analysis | … mice treated with AgNPs over 24 hours, and mice treated with AgNPs over 72 hours were stained for apoptotic nuclei by using the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphatase nick end labeling (TUNEL) assay (GenScript USA Inc, Piscataway, NJ … | Get A Quote |
Nanoparticles can potentially cause adverse effects on organs, tissue, cell levels, and protein levels because of their physicochemical properties. Silver nanoparticles (AgNPs) are being used on a wide scale in world consumer markets; their potential hazards for humans remain largely unknown. This study aimed to investigate the intraperitoneal toxicity of AgNPs (26 mg per kg of body weight, 52 mg per kg of body weight, and 78 mg per kg of body weight) over 72 hours in Swiss albino mice. AgNPs induced a significant increase in serum liver injury markers including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. Induction of DNA damage was also studied in mice injected... More