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Chemical shift assignments of a calmodulin intermediate with two Ca bound in complex with the IQ-motif of voltage-gated Ca channels (Ca1.2).

Biomol NMR Assign. 2019;

SalvesonIan，AndersonDavid E，HellJohannes W，AmesJam

Products/Services Used	Details	Operation
Peptide Synthesis	… chromatography (Gopalakrishna and Anderson 1982). A peptide fragment of the Cav1.2 IQ-motif (residues 1642–1665) was purchased from GenScript, dissolved in DMSO-d6 and quantified using UV–Vis absorption. A 1.5-fold excess of …	Get A Quote

摘要

Calcium-dependent inactivation (CDI) of neuronal voltage-gated Ca channels (Ca1.2) is important for synaptic plasticity， which is associated with learning and memory. The Ca-dependent binding of calmodulin (CaM) to Ca1.2 is essential for CDI. Here we report NMR assignments for a CaM mutant (D21A/D23A/D25A/E32Q/D57A/D59A/N61A/E68Q， called CaM) that contains two Ca bound at the third and fourth EF-hands (EF3 and EF4) and is bound to the IQ-motif (residues 1644-1665) from Ca1.2 (BMRB accession no. 27692).