资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

C23， an oligopeptide derived from cold-inducible RNA-binding protein， suppresses inflammation and reduces lung injury in neonatal sepsis.

J. Pediatr. Surg.. 2019;

DenningNaomi-Liza，YangWeng-Lang，HansenLaura，PrinceJose，Wang

Products/Services Used	Details	Operation
Peptide Synthesis	… group received a retroorbital injection of 8 mg/kg BW C23 (GRGFSRGGGDRGYGG synthesized from GenScript, Piscataway, NJ … Serum levels of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) were determined using specific colorimetric enzymatic assays …	Get A Quote

摘要

Neonatal sepsis remains a leading cause of infant mortality. Cold-inducible RNA binding protein (CIRP) is an inflammatory mediator that induces TNF-α production in macrophages. C23 is a CIRP-derived peptide that blocks CIRP from binding its receptor. We therefore hypothesized that treatment with C23 reduces systemic inflammation and protects the lungs in neonatal sepsis.