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EPB41L5 Mediates TGFβ-Induced Metastasis of Gastric Cancer.

Clin. Cancer Res.. 2019;

JeongMi-Hyeon，ParkSoo-Yeon，LeeSeung-Hyun，SeoJaeSung，YooJung-Yoon，ParkSeung-Ho，KimMi Jeong，LeeSooYeon，JangSubhin，ChoiHyo-Kyoung，LeeJae Eun，ShinSu-Jin，ChoiKyung-Chul，CheongJae-Ho，YoonHo-

Products/Services Used	Details	Operation
Peptide Synthesis	… using 164 EPB41L5 constructs and siRNA. A synthetic blocking peptide against EPB41L5 mAb was 165 synthesised and purchased from GenScript (NJ, USA). 166 167 Immunoprecipitation and Western blot analysis 168 The …	Get A Quote

摘要

Because of disease heterogeneity， limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal and breast cancer metastasis. However， its role in metastatic gastric cancer remains unknown. The specimens of 78 gastric cancer patients were analyzed by oligonucleotide microarray and survival analysis. experiments and metastatic mice models were used to assess the effects of EPB41L5 on gastric cancer metastasis. Gastric cancer patients with high EPB41L5 levels had poor prognosis and low survival rate. Further， TGFβ1-induced EPB41L5 expression promoted gastric cancer cell migrat... More