资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Decreased expression of cystathionine β-synthase exacerbates intestinal barrier injury in ulcerative colitis.

J Crohns Colitis. 2019;

ChenShanwen，ZuoShuai，ZhuJing，YueTaohua，BuDingfang，WangXin，WangPengyuan，PanYisheng，LiuY

Products/Services Used	Details	Operation
Recombinant Proteins	… [21] . Nuclear protein extracts were prepared according to the manufacturer's instructions (Thermo Pierce, USA). Briefly, Caco-2 monolayers were washed with PBS and … electrophoresed in 4-12% polyacrylamide gels (GenScript). Subsequently, the Page 8. Accepted Manuscript …	Get A Quote

摘要

Endogenous hydrogen sulfide (H2S) regulates multiple physiological and pathological processes in colon epithelial tissues. The current study investigated the role of cystathionine β-synthase (CBS)， a major producer of H2S in colon epithelial cells， in the pathogenesis of UC-related intestinal barrier injury. The expression and DNA methylation level of CBS were investigated in inflamed and non-inflamed colon tissues collected from UC patients， and the effect of decreased CBS levels on Caco-2 monolayer barrier injury and altered status of tight junctions elicited by TNF/IFN was determined.